Tony Gallacher, Isaac Christie-Davies, Luis Longstaff, Morgan Boyes and Thomas Hill all make their first ever senior appearances for the Reds at Villa Park.
Pedro Chirivella captains the team, which will be managed by U23s boss Neil Critchley.
Liverpool: Kelleher, Hoever, Boyes, Van den Berg, Gallacher, Chirivella, Christie-Davies, Kane, Longstaff, Hill, Elliott.
Substitutes: Winterbottom, Clayton, Dixon-Bonner, Bearne, Clarkson, Norris, Stewart.