The Senegal international, who joined Liverpool from Southampton in June 2016, will play his 100th match for the club if selected at the Amex Stadium.
Mane has scored 42 goals for the Reds, against 23 different opponents, but is yet to find the net against Brighton.
For more need-to-know pre-match facts and figures, courtesy of club statistician Ged Rea, read on...
Liverpool have won 16, drawn eight and lost only four of 28 meetings in all competitions with the Seagulls. At Brighton, the Reds have won six and lost two with five draws.