The Senegalese forward is just one goal short of becoming the 10th Reds player to net 50 Premier League strikes for the club.
Mane netted in the reverse fixture against Chelsea last season and bagged a brace in last month's UEFA Super Cup victory over the Blues.
For more need-to-know pre-match facts and figures, courtesy of club statistician Ged Rea, read on...
Since the inception of the Premier League, Liverpool and Chelsea have played each other 54 times and are tied on 20 wins apiece, with 14 draws.
A win at Stamford Bridge on Sunday would see the Reds set a new club record of seven successive league wins away from home.