The 24-year-old defender, who joined the club from Hull City in July last year, will play his 50th match for the Reds if selected for the Group C tie at Anfield.
Liverpool will guarantee their place in the knockout stage of UEFA's flagship competition if they beat Napoli 1-0 or win by at least a two-goal margin.
For more need-to-know pre-match facts and figures, courtesy of club statistician Ged Rea, read on...
Liverpool have lost just one of their last 23 European games at Anfield and are unbeaten in the last 18 at home, winning 13 and drawing five.