Jürgen Klopp's European champions begin the defence of their crown at Stadio San Paolo and, if Firmino is selected for the Group E fixture, the game will bring up his double century for the Reds.
The Brazilian forward has played in 41 of Liverpool's 42 games in Europe under Klopp, missing only the second leg of last season's semi-final against Barcelona during the boss' tenure.
For more need-to-know pre-match facts and figures, courtesy of club statistician Ged Rea, read on...
Liverpool are unbeaten in 13 opening group games of a European campaign (eight wins and five draws) since losing at Valencia in 2002.