Jürgen Klopp's men are on a 15-game winning streak overall in the top flight, but the Reds have never won a Premier League game at Bramall Lane.
With two draws and a loss at the home of the Blades, it is one of only three grounds Liverpool have played at without winning in the division - along with Nottingham Forest's City Ground (five visits) and Blackpool's Bloomfield Road (one visit).
For more need-to-know pre-match facts and figures, courtesy of club statistician Ged Rea, read on...
Liverpool and Sheffield United have met six times in the Premier League and are tied in their head-to-head at two wins apiece and two draws.