Should the Reds avoid defeat at Anfield, they will set a new club record of 16 consecutive matches unbeaten against the Blues across all competitions.
For more fascinating pre-match facts, courtesy of club statistician Ged Rea, read on...
Liverpool have met Everton in the FA Cup more times than any other team. This will be the 18th FA Cup tie in which the Merseysiders have faced each other, with the Reds coming out on top in 10 of them.
However, the clubs have only met four times at Anfield in the competition, with all of those matches ending in draws.