Should Jürgen Klopp's side triumph at Goodison Park, it will be the Reds' 680th victory on the road in the English top flight, beating the landmark previously set by Arsenal.
The boss is unbeaten in five derby clashes in all competitions and won the last Premier League trip to Everton 1-0 thanks to a last-gasp Sadio Mane strike.
For more need-to-know pre-match facts and figures courtesy of club statistician Ged Rea, read on...
Liverpool have won as many Merseyside derbies at Goodison as Everton have - 40 each in all competitions.
And the Reds have scored 119 away goals in league derbies, just two fewer than the Blues themselves.