The 28-year-old midfielder will play the 300th Premier League match of his career if selected at the London Stadium.
Henderson made 71 top-flight appearances for boyhood club Sunderland before moving to Anfield in June 2011 and racking up another 228 so far.
For more need-to-know pre-match facts and figures, courtesy of club statistician Ged Rea, read on...
Liverpool have scored four or more goals in a record four successive games against West Ham - 4-0 (a), 4-1 (a), 4-1 (h), 4-0 (h). The Reds had never previously achieved the feat against any team in their top-flight history.