The midfielder could play his 200th Premier League match for the Reds if selected at Old Trafford.
The 27-year-old is one of only two men available today that were also part of the last LFC matchday squad to triumph at United - Henderson and Simon Mignolet helped secure a 3-0 win at Old Trafford in March 2014.
For more need-to-know pre-match facts and figures courtesy of club statistician Ged Rea, read on...
This will be the 200th meeting between Liverpool and United in all competitions.
The last four meetings between the clubs, home and away, have ended in a draw.