The League One side will be the 68th different opponent the Reds have faced in the cup competition they have won more times than any other club.
Burton Albion, who Jürgen Klopp's men beat 5-0 three seasons ago, were the last team Liverpool had met for the first time.
For more need-to-know pre-match facts and figures, courtesy of club statistician Ged Rea, read on...
The last time the Reds met a side outside the top two divisions was in 2015 when they required penalties to defeat Carlisle United at Anfield after a 1-1 draw.