The Reds have won 70 of the previous 99 games staged at the iconic stadium, with 17 draws and 12 losses.
Salzburg will become the 76th different club Liverpool have faced in the Champions League and its previous guises when the Group E opponents meet for the first time.
For more need-to-know pre-match facts and figures, courtesy of club statistician Ged Rea, read on...
Salzburg will be the fourth team from Austria to face Liverpool, following Austria Vienna, Swarovski Tirol and AK Graz.
The Reds defeated Austria Vienna in the quarter-final of the European Cup in 1985, winning 4-1 at Anfield for a 5-2 aggregate victory.