Jürgen Klopp intends to balance the physical effects of the Emirates FA Cup final with the need to win at Southampton, but Liverpool are set to be without Mohamed Salah and Virgil van Dijk at St Mary's.
Three days on from beating Chelsea in a penalty shootout at Wembley after a draining 120 minutes of play, the Reds return to Premier League duty on Tuesday night looking to reduce the gap to leaders Manchester City to a point ahead of the final matchday.
Salah and Van Dijk are going to miss the journey to the south coast, however, having been taken off on the half-hour and 90 minutes respectively in the FA Cup final due to issues felt during the contest.