Liverpool forward Darwin Nunez has recovered from the toe injury which has kept him out for the past few weeks.
Defender Ibrahima Konate is struggling with illness, while Andrew Robertson is nursing a groin issue.
Thiago Alcantara, Stefan Bajcetic and Calvin Ramsey will return next season.
Southampton will be without striker Che Adams due to a recurring calf issue, while fellow forward Paul Onuachu is a doubt with a back problem.
Defenders Armel Bella-Kotchap, Juan Larios and Mohamed Salisu all remain sidelined.
CHRIS SUTTON'S PREDICTION
Southampton don't have too many fond memories to look back on this season, especially at home where they have only won twice during the entire campaign.