Goals from Naby Keita, Mohamed Salah and Jordan Henderson saw the Reds overcome Shane Long's ninth-minute opener at St Mary's on Friday.
Here are five talking points from the south coast...
Defiant Liverpool turn it around again
The character and resilience of this Liverpool team is clear to see. They have now won seven of their last eight Premier League games when conceding first.
Jürgen Klopp's side recovered from an early setback to secure a vital three points in the title race.
"It’s brilliant," the Reds boss said of his players' mentality afterwards.