The popular defender has decided to return to America to be closer to her family.
The Women’s FA Cup fifth-round clash with Millwall Lionesses at Prenton Park on Sunday will be the 25-year-old’s final game with the Reds.
Murray joined LFC Women in January 2015 from college football in the States and has gone on to make 68 appearances at centre-back and right-back, scoring two goals and becoming a fan favourite.
“This decision is not easy, Liverpool is like home. Having to leave is the hardest decision in the world,” she said.
“But my family and friends have always been really supportive of me and they’re ready for me to go home.