Liverpool U21s were eliminated from the Leasing.com Trophy after a 5-2 defeat at Accrington Stanley on Tuesday night.
The young Reds' maiden campaign in the competition ends in the group stages after amassing one point from three matches.
Elijah Dixon-Bonner gave Neil Critchley's side the lead at the Wham Stadium after eight minutes when he completed a well-worked counter-attack.
But clinical goals from Ross Sykes, Courtney Baker-Richardson, Dion Charles, Jordan Clark and Connor Simpson saw the League One claim the victory.
Layton Stewart pulled one back for Liverpool in the 77th minute to complete the scoring.