The centre-back spent the majority of the match in and around the centre-circle at the John Smith's Stadium as the Reds enjoyed 74.8 per cent possession against the Terriers.
Matip attemped 161 passes - with a team-leading passing accuracy of 95.7 per cent - to beat Jordan Henderson's previous club record of 133 against Burnley in August 2016.
Matip's tally also ranks him third in the Premier League's all-time list, behind Arsenal's Santiago Cazorla, who completed 162 passes against Sunderland in May 2015, and Manchester City's Yaya Toure, who notched 168 against Stoke City in December 2011.