The winner will walk away with £20,000 as well as the title of ePL Champion 2019-20.
Online qualification begins on Monday December 2 and fans can register now at e.premierleague.com.
After a hugely successful debut ePL season, the tournament returns for UK-based FIFA players to compete on either PlayStation 4 or Xbox One. Registration is open until the end of the qualification period on December 22.
Once the most talented have made the cut, each club will host their own playoffs, with the best of the best appearing at the ePL Finals in London in March.