Premier League sides are among leading European clubs set to prevent players from going to red-list countries for September's international break.
Unless quarantine exemptions are made, players would be forced to miss several domestic league matches because of the 10-day isolation period required on return to the UK.
The Football Association and Premier League are in talks with the Department for Digital, Culture, Media and Sport (DCMS) over a relaxation of UK rules. Similar problems are thought to confront clubs across Europe.
Liverpool are among the clubs refusing to release players for international duty.
Four Reds players are affected - Egypt forward Mohamed Salah and Brazil trio Alisson, Fabinho and Roberto Firmino - because their home nations are on the UK government's red list.