The Group E encounter at Anfield is the German's 47th continental tie in charge of the Reds - the same number he recorded in seven seasons with Borussia Dortmund.
FSV Mainz 05 were the first team he guided into European competition, taking charge of six UEFA Cup qualifying fixtures in the 2005-06 campaign.
Of his previous 99 matches, Klopp has won 53 of them, recording 21 draws and suffering 25 defeats.
For more need-to-know pre-match facts and figures, courtesy of club statistician Ged Rea, read on...
Liverpool will be through to the knockout stages of the Champions League if they beat Napoli, or if Salzburg do not beat Genk.