The boss has faced the Reds' local rivals on nine previous occasions since taking charge in October 2015, winning six of them and drawing three.
Should he avoid defeat in this latest encounter, the German would equal the club record of most derbies undefeated from the start of a managerial career that's currently held by Bob Paisley (10).
For more need-to-know pre-match facts and figures, courtesy of club statistician Ged Rea, read on...
This will be the 25th meeting between the clubs in this competition, making it the most-played fixture in FA Cup history.