Brian Conroy is used to the cold nipping at his fingers and toes after a lifetime in construction work and fishing in all weathers at weekends. But his hands and feet are now being deliberately cooled in a clinical trial - the first of its kind in the NHS - looking at reducing one of the most debilitating side-effects of chemotherapy: peripheral neuropathy.
This type of nerve damage can cause constant pain, as well as a tingling sensation, weakness or numbness, in the fingers and toes.
While for some the side-effect is short term, in many others it lasts for months, years or becomes permanent.