Darwin Nunez scored as Uruguay began their Copa America campaign with a 3-1 win over Panama in Miami, Florida.
The Liverpool striker, 25, volleyed home at the near post with five minutes of normal time remaining to double Uruguay's lead after defender Ronald Araujo had opened the scoring after 16 minutes.
Left-back Matias Vina added a third in added time for the 15-time champions, before defender Michael Amir Murillo scored a consolation for Panama.
"When it comes to Uruguay's aspirations, we will see that and build it match by match," said Uruguay manager Marcelo Bielsa.