Liverpool manager Arne Slot says the defeat at Plymouth Argyle was "not acceptable" and that his side have to bounce back against Everton in the Merseyside derby on Wednesday (19:30 GMT).
A much-changed Reds side were on the end of an FA Cup upset when they were beaten 1-0 at Plymouth, who are bottom of the Championship, on Sunday.
They now face Everton in the Premier League as they aim to extend their lead at the top of the table to nine points in what is set to be the final Merseyside derby at Goodison Park.