Liverpool's Egyptian claims the prize for the first time this season after scoring five goals in his four top-flight appearances during the month.
He ended up beating the shortlisted Ben Chilwell, Maxwell Cornet, Phil Foden, Valentino Livramento, Aaron Ramsdale, Declan Rice and Youri Tielemans to win the accolade.
Salah began October by scoring a stunning solo goal at Anfield against Manchester City, having initially done brilliantly to set up Sadio Mane's opener.
The No.11 then followed that up with another piece of magic away at Watford, before becoming the first-ever opposition player to score a Premier League hat-trick at Old Trafford during the Reds' 5-0 win over Manchester United.