The midfielder, who is Neil Critchley’s team’s top scorer this season with six goals, was forced off late on during the 3-1 home win over Leicester City at the start of November.
And Critchley confirmed on Tuesday that the 21-year-old is set for a spell on the sidelines.
“Matty is going to be out for a good few weeks unfortunately,” the U23s boss told Liverpoolfc.com.
“We showed a great response to the defeat at Blackburn by beating Leicester City, but that victory was somewhat soured and dampened by Matty’s injury.
“It was an innocuous incident where he went over on his ankle.