Liverpool U23s suffered a 3-0 defeat away at Wigan Athletic in the Premier League Cup on Friday night.
An Emeka Obi header broke the deadlock early on at the Lancashire FA County Ground and was followed by Divin Baningime's clinical finish in the 32nd minute.
The young Reds were unable to convert numerous chances in front of goal and their first defeat of the group phase was confirmed when Olly Crankshaw added the third during the second half.
The hosts made an encouraging start to the affair and Luke Robinson fired early notices to Neil Critchley's side about his threatening delivery from dead-ball situations.