Baggies forward Jovan Malcolm netted four first-half goals in the U18s Premier League North clash, with Alex Gilbert and Rico Richards also on the scoresheet.
Consolation goals came through Max Woltman's brace and one from Conor Bradley as the young Reds will look to respond against Southampton following the international break.
The visitors nearly made the perfect start and could have found themselves in front after 21 seconds. James Norris, however, headed just wide from Tom Hill's dink into the box.
And West Brom responded with six goals within the space of half an hour to take an unassailable advantage.