Doubles from strikers Layton Stewart and James Balagizi, plus two from midfielder Tom Hill and a Jake Cain strike, saw the young Reds to a decisive win despite difficult weather conditions.
A much-changed line-up from last season saw just two players, Cain and Leighton Clarkson, remain from the starting team in the FA Youth Cup final.
But a young side started impressively with full-backs James Norris and Jarell Quansah getting forward well.
Liverpool took the lead on eight minutes with Stewart pouncing on a loose ball to head home after Cain’s header had been fumbled by the Blackburn goalkeeper.