Nathaniel Clyne, Rhian Brewster (two), Curtis Jones, Divock Origi and Bobby Duncan were the goalscorers as Jürgen Klopp’s side kicked off their seven-game build-up to the campaign in emphatic fashion.
The manager gave minutes to 23 players at Prenton Park in front of a sell-out crowd for the meeting with the League One team.
An energetic beginning to the contest was punctuated by Liverpool’s first goal of 2019-20 with just six minutes on the clock.
Its genesis was a surging run from his own half by Joe Gomez, whose eventual pass into Brewster was swiftly turned out to the right channel for Clyne to dispatch an excellent rising finish high into the Tranmere net.