Neil Critchley's side still remain at the top of the division, but second-placed Arsenal have now closed the gap to just one point.
Following back-to-back defeats to Tottenham Hotspur and Bristol City in league and cup, the young Reds will be looking for a response against the Hammers.
Read on for more details on tonight's encounter...
Where is the game being played? The match is taking place at the Kirkby Academy with kick-off set for 3pm GMT.
How can I watch the game? We will have highlights on LFCTV GO on Saturday night and the match will be shown in full with delayed coverage on LFCTV.