Neil Critchley's side lost 3-1 at home to Swansea City on Friday and will hope to put that defeat behind them against the Dutch outfit in their final outing of 2017.
After a victory over Newcastle United and a defeat against Sparta Prague, the young Reds must beat PSV to stand any chance of reaching the quarter-finals of the competition.
There are six four-team groups in the Premier League International Cup, which feature two English sides and two of their European counterparts. The group winners and the two best runners-up will make the last eight.
Ahead of Tuesday's encounter at Tranmere Rovers FC, here is our match preview.