Neil Critchley's side will be aiming to bounce back to winning ways following the midweek 1-0 loss to Sparta Prague in the Premier League International Cup.
So far in the Premier League U23 Cup, Neil Critchley's side were held to a 1-1 draw away at Charlton Athletic in their opening game but then thrashed Bristol City 7-0 in their last group match.
Stoke City started with a 3-1 defeat to Bristol City before recording a 3-1 win over Charlton at St George's Park.
After home and away clashes with each team in the group, the top two will progress to the knockout stage.