Manchester United may be able to welcome back Anthony Martial, who is training after a thigh injury.
Liverpool striker Darwin Nunez begins a three-match ban for his headbutt during the draw against Crystal Palace last Monday night.
The Reds are boosted by the return of Roberto Firmino but Thiago, Diogo Jota and Joel Matip remain out.
CHRIS SUTTON'S PREDICTION
If Manchester United win this game, they leapfrog Liverpool in the table, but that is not going to happen.
United aren't able to press teams with the players they have got, and I don't really know what Erik ten Hag can change with what he has got in his squad.