Defender Manuel Akanji has been ruled out of Manchester City's Champions League return with Real Madrid and their Premier League clash with Liverpool amid fears he could be set for an extended absence with a muscular problem.
The Switzerland international was replaced at half-time in the 3-2 defeat by Real at the Etihad Stadium on Tuesday.
City face Real in the second leg next Wednesday before hosting Liverpool on Sunday 23 February.
Manager Pep Guardiola was not asked about Akanji in the aftermath of the game but is expected to offer an update on the 29-year-old, as well as forward Jack Grealish - who was replaced in the first-half - when he holds his regular media briefing on Friday ahead of his side's game with Newcastle on Saturday.