The defender came on as a substitute after half an hour of the Reds’ FA Women’s Championship win over Coventry United Ladies.
At just 16 years and 150 days, Parry broke the age record set by Maz Pacheco, who was 16 years and 212 days when she made her debut.
Parry replaced Becky Jane in a planned change with the right-back herself making her first appearance of the season on her comeback from injury.
The new record-breaker is an Academy graduate as a member of the Regional Talent Club.
LFC Women won the game 2-1 with goals from Melissa Lawley and Amalie Thestrup, her first for the club.