On-loan Liverpool forward Origi started as a lone striker at Signal Iduna Park and helped Martin Schmidt's side take a hard-earned point from their first Bundesliga fixture following the mid-season break.
Sheyi Ojo, meanwhile, started for Fulham in their dramatic 1-0 victory at fellow Championship play-off chasers Middlesbrough - a result secured by a 95th-minute winner.
Elsewhere, Ryan Kent made his debut for Bristol City as a substitute in their 1-0 home defeat to Norwich City, and Allan Rodrigues de Souza played as Apollon Limassol drew 1-1 with Anorthosis Famagusta in a clash between the third and fourth-placed teams in Cyprus.