Liverpool are without Fabinho because of a hamstring problem, so 19-year-old centre-back Rhys Williams could make his Premier League debut.
The Reds will monitor the fitness of Thiago Alcantara and Naby Keita, who are nearing returns, while this game may come too soon for Joel Matip.
Michail Antonio is absent for West Ham but boss David Moyes does not think the player's hamstring injury is "too bad".
The striker could be replaced by Sebastien Haller at Anfield.
Deadline-day signing Said Benrahma awaits his Hammers debut, having not been involved against Manchester City last weekend because of a lack of match fitness.