Fabinho looks set to continue deputising for Virgil van Dijk in Liverpool's defence after impressing in the Champions League win at Ajax.
There is still no timescale on Van Dijk's absence with a knee injury, while Joel Matip and Thiago Alcantara will be assessed.
Rhian Brewster could make his first Premier League start for Sheffield United on his return to Anfield.
John Fleck and Lys Mousset will both miss around six weeks through injury.
Manager Chris Wilder is already without defender Jack O'Connell, while Max Lowe's Premier League debut was cut short last Sunday after he suffered a concussion.