Liverpool may need to monitor Harvey Elliott, who was replaced at half-time against Bournemouth as a precaution, though boss Jurgen Klopp is optimistic the midfielder will be available.
Darwin Nunez completes a three-game suspension.
Newcastle's record signing Alexander Isak will only make his debut if his work permit arrives in time.
Bruno Guimaraes is set to miss a second match because of a minor injury, Callum Wilson is still absent, while Allan Saint-Maximin and Kieran Trippier may also need to be assessed.
Emil Krafth, meanwhile, is likely to be out for at least six months after tearing his anterior cruciate ligament in last week's EFL Cup win at Tranmere.