Defender Calvin Ramsey could make his first senior appearance for Liverpool and Ibrahima Konate may also feature against Napoli in the Champions League.
Cameroon defender Joel Matip, who has not featured since 9 October because of a calf strain, is still missing.
Napoli top Group A on 15 points while the Reds are also through to the last 16 with one game to spare.
France defender Konate, 23, has only featured twice for the Reds this season because of injury.
"Ibou, I think there's a good chance that he will have a game," said Liverpool boss Jurgen Klopp on Monday.