Liverpool manager Jurgen Klopp is likely to make changes after the FA Cup semi-final win over Manchester City.
Jordan Henderson, Joel Matip and Diogo Jota could all return to the side after they were benched at Wembley.
Manchester United will hope to welcome back Raphael Varane from a minor injury which saw the defender miss the past two matches.
Midfielders Fred and Scott McTominay are struggling to overcome respective hip and foot issues.
Luke Shaw and Edinson Cavani remain sidelined.
MATCH FACTS
Head-to-head
- Liverpool are unbeaten in seven Premier League meetings with Manchester United (W4, D3).