But how have the Reds fared in their four previous meetings with the Azuis e Brancos?
Allow our 'brief history' of the fixture to fill you in...
Porto 0-0 Liverpool (March 8, 2001)
This UEFA Cup quarter-final first leg at Porto’s former home, the Estadio Das Antas, was the clubs’ first competitive clash.
Having dispatched Italian champions AS Roma in the previous round, Gerard Houllier’s Liverpool travelled to Portugal looking to extend their unbeaten away record in that season’s competition - which they would, of course, go on to win two months later.