Liverpool will try everything to quickly get Ben Davies and Ozan Kabak up to speed tactically, but starts for the pair against Brighton & Hove Albion are unlikely.
The defensive duo joined the Reds on transfer deadline day to bolster Jürgen Klopp's options in the heart of the backline.
Speaking on Tuesday, Klopp told reporters: "We play obviously different to Preston and obviously different to Schalke, that's clear.
"They will need time but we don't have a lot of time. So we will use the time we have in our hands and try our best.
"So if they would have to start tomorrow night together, I think that would be not too cool.