Liverpool forward Sadio Mane and full-back Andy Robertson are both expected to feature despite sustaining respective rib and hamstring injuries on international duty.
Jordan Henderson will be assessed, while Roberto Firmino, James Milner and Naby Keita remain out.
Arsenal midfielder Thomas Partey is available after he missed the win over Watford with a muscular issue.
Sead Kolasinac has been ruled out because of an ankle injury.
LAWRO'S PREDICTION
Arsenal are unbeaten in their past 10 games in all competitions but this is by far their biggest test since that run started.
I know they won at Leicester in October but arguably their best player that day was goalkeeper Aaron Ramsdale, who made save after save.