Liverpool captain Jordan Henderson will not recover in time from the foot injury suffered in training before the loss at Leicester.
Dejan Lovren has not played since 31 January but is back in training and will be assessed ahead of the game.
Mesut Ozil was sent home from Arsenal's training session on Thursday with an illness but is expected to be fit.
Aaron Ramsey and Laurent Koscielny return but Mohamed Elneny is out for three weeks with an ankle injury.
MOTD COMMENTATOR'S NOTES
Jonathan Pearce: "Ever since commentating on the epic 1989 title clincher, this has been one of my favourite fixtures.