Liverpool left-back Andy Robertson will miss Tuesday's Champions League game with Ajax after injuring his knee.
Midfielders Curtis Jones, Naby Keita and Alex Oxlade-Chamberlain are all sidelined too.
The Reds lost 4-1 at Napoli in the Group A opener, in what boss Jurgen Klopp called "the worst game we played since I was here" with Ajax beating Rangers 4-0 in the other game.
Ajax's only injury absentee is Netherlands left-back Owen Wijndal, who is out with an ankle problem.
The Dutch side have won all seven games in all competitions this season, with an aggregate score of 25-3.