Liverpool are in talks to sign Preston's Ben Davies for £2m as they look to find a solution for their central defensive crisis.
Joel Matip has joined Virgil van Dijk and Joe Gomez on the injury list.
And Fabinho, who has dropped back from midfield for most of the season, was also ruled out at London Stadium.
Davies, 25, came through Preston's youth system and has had spells on loan with York, Southport and Newport. He is expected to undergo a medical with Liverpool on Monday.
He has made 19 appearances for Preston this season and completed the full 90 minutes in Saturday's defeat at Sheffield Wednesday.