The clash between the Reds and the Blues will take place on Sunday February 9, with kick-off at 2pm GMT.
It will be the second derby to be hosted at a first-team stadium this season after a record crowd of 23,500 watched the two teams meet at Anfield in November.
“It’s fantastic that we’ve got another match in which to showcase the women’s game on Merseyside,” said LFC Women manager Vicky Jepson.
“The Anfield derby was a terrific occasion and I hope as many Reds as possible will cross the park to cheer on the team at another historic football venue.